Is Targretin chemotherapy?

Bexarotene (Targretin®) is a Chemotherapy Regimen for Lymphoma, T-Cell.

What is Targretin used for?

TARGRETIN (bexarotene) capsules and gel are used to treat the skin problems arising from a disease called cutaneous T-cell lymphoma, or CTCL, in patients who have not responded well to other treatments. Your healthcare provider must supervise the use of TARGRETIN.

Is bexarotene cytotoxic?

Organometallic compounds in which bexarotene is tethered to the ruthenium(II) arene unit, i.e. complexes 4 and 5, were prepared and found to exhibit a high cytotoxicity to human ovarian cancer cells, being more effective than cisplatin, and exhibiting a modest degree of cancer cell selectivity.

What are the side effects of bexarotene?

More common

  • Unusual tiredness or weakness.
  • skin rash or other skin and mucous membrane lesions.
  • increase in lipid or cholesterol levels.
  • coldness, dry, puffy skin or weight gain.
  • chills, cough, hoarseness, lower back or side pain or painful or difficult urination.
  • swelling of the arms, feet, hands, or legs.

How long can you take bexarotene?

Usual Adult Dose for Cutaneous T-cell Lymphoma: Duration of Therapy: This drug should be continued as long as the patient is deriving benefit. In clinical trials with CTCL patients, this drug was administered for up to 118 weeks.

What are the side effects of levothyroxine?

Levothyroxine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • weight gain or loss.
  • headache.
  • vomiting.
  • diarrhea.
  • changes in appetite.
  • fever.
  • changes in menstrual cycle.
  • sensitivity to heat.

Who should not take acitretin?

Do not take acitretin if you are pregnant or plan to become pregnant within the next 3 years. Acitretin may harm the fetus. You should not begin taking acitretin until you have taken two pregnancy tests with negative results.

How long can you take acitretin?

A course of treatment is likely to last for up to six months but occasionally it can be for longer than this. Acitretin is harmful to unborn babies, so it is very important that you do not become pregnant while you are taking it.

What is the best treatment for mycosis fungoides?

Treatment of newly diagnosed stage I and stage II mycosis fungoides may include the following:

  • Psoralen and ultraviolet A (PUVA) radiation therapy.
  • Ultraviolet B radiation therapy.
  • Radiation therapy with total skin electron beam radiation therapy.
  • Immunotherapy given alone or combined with therapy directed at the skin.

What do you need to know about Targretin capsules?

PACKAGE INSERT Targretin®(bexarotene) capsules, 75 mg Rx only. DESCRIPTION Targretin®(bexarotene) is a member of a subclass of retinoids that selectively activate retinoid X receptors (RXRs). These retinoid receptors have biologic activity distinct from that of retinoic acid receptors (RARs).

When was bexarotene approved for the treatment of CTCL?

Bexarotene. Bexarotene (brand name: Targretin) is an antineoplastic (anti-cancer) agent approved by the U.S.Food and Drug Administration (FDA) (in late 1999) and the European Medicines Agency (EMA) (early 2001) for use as a treatment for cutaneous T cell lymphoma (CTCL). It is a third-generation retinoid .

Can a drug called bexarotene be used for remyelination?

The results of CCMR-One, a clinical trial of the effects of bexarotene on patients with multiple sclerosis operated by the University of Cambridge, have shown that the drug can cause remyelination, but will not lead to the drug being used as a therapy, due to its risk profile.

How does bexarotene prevent the development of drug resistance?

Bexarotene is a retinoid that selectively activates retinoid X receptors (RXRs), as opposed to the retinoic acid receptors, the other major target of retinoic acid (the acid form of vitamin A ). By so doing it induces cell differentiation and apoptosis and prevents the development of drug resistance.