What are squamous morules?

Squamous morules are a common component of premalignant glandular lesions that are followed by. glandular, rather than squamous, carcinomas. We tested the hypothesis that the appearance of glands. associated with morules predicts cancer risk, and undertook molecular testing to determine the clonal and.

What is endometrial squamous metaplasia?

Squamous Metaplasia. The most common protective mechanism of the endocervical epithelium of the uterine cervix is squamous metaplasia. The term metaplasia implies the transformation of one cell type into another type of cell, the latter being of a lower organizational order.

What is extensive squamous metaplasia?

The term ‘morulosis’ indicates extensive squamous mulberry-like metaplasia, which in a large part or nearly entirely affects endometrium, whereas in turn, benign squamous metaplasia or single morules, refers to a limited, usually small regional pathology of endometrium.

What is tubal metaplasia?

Introduction. Tubal (or ciliated cell) metaplasia of the endometrium is characterized by ciliated columnar cells with bland round nuclei and eosinophilic cytoplasm, similar to the cells normally seen lining the fallopian tube [1]. It is generally thought that endometrial tubal metaplasia (ETM) is a benign disease.

Is squamous metaplasia normal?

There are two types of squamous metaplasia of the urothelium, nonkeratinizing and keratinizing. The former is considered as a normal finding in females, present in the trigone and bladder neck in up to 85% of women of reproductive age and 75% of postmenopausal women.

What is squamous morule formation?

Squamous morules are a common component of premalignant glandular lesions that are followed by glandular, rather than squamous, carcinomas.

Is squamous metaplasia precancerous?

Squamous metaplasia is a benign non-cancerous change (metaplasia) of surfacing lining cells (epithelium) to a squamous morphology.

How is squamous metaplasia treated?

Conclusion: The therapeutic management of keratinizing squamous metaplasia is controversial, and currently no effective medical therapy is available for its treatment. Actually, patients undergo transurethral resections and a multidisciplinary approach is required to avoid cystectomy.

What causes tubal metaplasia?

Tubal metaplasia occurs in setting of estrogen excess or postmenopausal. Squamous metaplasia frequently occurs in hyperplasia, neoplasia, CEMI. The endometrium looks very much like the epithelium of the fallopian tube. Cilia are present.

What causes squamous metaplasia?

Factors in the initiation and promotion of squamous metaplasia are chronic irritation of a physical nature, such as that caused by an intrauterine contraceptive device (IUD), chemical irritants, inflammation with cell destruction, and endocrine changes at the beginning of, during, and after reproductive age.

What causes squamous metaplasia in the cervix?

What is non atypical hyperplasia?

Endometrial hyperplasia is an excessive thickening of the lining of the uterus. In non-atypical endometrial hyperplasia, the cells are normal, but there are too many of them. Endometrial hyperplasia can result in heavier than usual bleeding during menstruation or bleeding after menopause.

How are squamous morules related to glandular cancer?

Squamous morules are a common component of premalignant glandular lesions that are followed by glandular, rather than squamous, carcinomas. We tested the hypothesis that the appearance of glands associated with morules predicts cancer risk, and undertook molecular testing to determine the clonal and …

What are the squamous morules in endometrial neoplasia?

Squamous morules are a common component of premalignant glandular lesions that are followed by glandular, rather than squamous, carcinomas.

Is it possible to have squamous metaplasia of uterine cervix?

Squamous Metaplasia of Uterine Cervix is a benign condition and there is no risk for a malignant transformation. There are no causative factors associated with Squamous Metaplasia of Uterine Cervix.

What are the features of atypical squamous metaplasia?

Atypical squamous metaplasia: In this condition, the squamous epithelium shows atypical features such as abnormal nucleus and mitotic activity. This usually occurs due to superimposed HPV infection. Atypical squamous metaplasia could potentially be a premalignant stage to squamous cell carcinoma of cervix