What is Ductular proliferation?
INTRODUCTION. Ductular proliferation is often used to describe the appearance of biliary epithelial cells in the portal tracts of diseased livers. The proliferating bile ductules are heterogeneous and are histologically classifiable into typical and atypical types.
What are Cholangiocytes?
Cholangiocytes are epithelial cells lining the intrahepatic and extrahepatic bile ducts; they are heterogeneous in size and function and contribute to bile composition and flow by solute transport processes.
What does bile duct proliferation mean?
Proliferation of bile duct-like structures is a hepatic cellular reaction observed in most forms of human liver disease and in a variety of experimental conditions associated with liver injury. Yet the origin, means of initiation, and significance of this hyperplasia are unknown.
Are cholangiocytes in the liver?
Function. In the healthy liver, cholangiocytes contribute to bile secretion via release of bicarbonate and water.
How many stages of PBC are there?
What are the stages? PBC has four stages. They’re based on how much damage has been done to the liver.
What kind of liver disease is ductular reaction?
Ductular reaction (DR) is characterized by the proliferation of reactive bile ducts induced by liver injuries. DR is pathologically recognized as bile duct hyperplasia and is commonly observed in biliary disorders. It can also be identified in various liver disorders including nonalcoholic fatty liver disease.
What are the scientific interests of ductular reaction?
DR raises scientific interests because it is associated with transdifferentiation of liver cells and may play an important role in hepatic regeneration.
Can a ductular reaction occur in a FLC?
(7) However, FNH exhibits prominent ductular reaction at the interface between fibrous septa and normal parenchyma, which is not observed in FLC. The histopathological findings especially peri-portal fibrosis and bile duct/ ductular hyperplasia are often seen in chronic toxicities.
Which is the best definition of the word ductular?
ductulus duct, epithelial duct, canal, channel – a bodily passage or tube lined with epithelial cells and conveying a secretion or other substance; “the tear duct was obstructed”; “the alimentary canal”; “poison is released through a channel in the snake’s fangs”