What is the pathophysiology of gastric cancer?

Gastric cancer consists of two pathological variants, intestinal and diffuse. The intestinal-type is the end-result of an inflammatory process that progresses from chronic gastritis to atrophic gastritis and finally to intestinal metaplasia and dysplasia.

What is the treatment of a proximal gastric cancer?

Depending on the site and extent of cancer, surgery is the only potentially curative treatment for all T1b-T4 gastric cancers, and extended lymphadenectomy (D2) should be recommended as standard of care in resectable gastric cancer, while endoscopic submucosal resection followed by close surveillance is the preferred …

Can stomach cancer be seen in ultrasound?

Endoscopic ultrasound (EUS) is often used to see how far a cancer might have spread into the wall of the stomach, or into nearby areas or nearby lymph nodes. For this test, a small ultrasound probe is placed on the tip of an endoscope.

Where does gastric cancer spread first?

The most common place for stomach cancer to spread is to the liver. It can also spread to the lungs, to lymph nodes or to the tissue lining the abdominal cavity (peritoneum).

What are the characteristics of Scirrhous gastric cancer?

Scirrhous gastric cancer cells easily invade and diffusely spread into the gastric wall. The common features of scirrhous gastric cancer include rapidly progressive invasion and a high frequency of metastasis to the peritoneum.

Is there a treatment for scirrhous gastric cancer?

The aim of this critical review is to discuss scirrhous gastric cancer. Conclusion. Despite an increase in the understanding of the molecular pathways involved in scirrhous gastric cancer, clinical studies have not identified agents that are effective in the treatment of this disease.

How often is scirrhous carcinoma of the stomach diagnosed?

During a recent 10-year period, scirrhous tumors of the stomach were diagnosed at upper gastrointestinal examinations in 27 patients in whom pathologic correlation was available. Nineteen patients underwent double-contrast studies, and eight underwent single-contrast studies.

What kind of carcinoma is found in the stomach?

Twenty-two of the 27 patients had primary gastric carcinoma, four had gastric involvement by metastatic breast cancer, and one had antral gastritis and scarring without evidence of malignancy.