Can spastic diplegia be hereditary?
Most people with pure hereditary spastic paraplegia will have inherited a faulty gene from 1 of their parents. People with the complicated form of the condition will have usually inherited a faulty gene from both parents.
Is HSP a progressive disease?
Hereditary spastic paraplegia (HSP), also called familial spastic paraparesis (FSP), refers to a group of inherited disorders that are characterized by progressive weakness and spasticity (stiffness) of the legs. Early in the disease course, there may be mild gait difficulties and stiffness.
Is Hereditary spastic paraplegia a developmental disability?
Related Disorders AP-4-associated hereditary spastic paraplegia (HSP) is a group of slowly-progressing neurodegenerative disorders that generally present with global developmental delay, moderate to severe intellectual disability, impaired/absent speech, microcephaly, seizures, and progressive motor symptoms.
Is spastic diplegia a disability?
Severe intellectual disability-progressive spastic diplegia syndrome is a rare, genetic, syndromic intellectual disability disorder characterized by intellectual disability, significant motor delay, severe speech impairment, early-onset truncal hypotonia with progressive distal hypertonia/spasticity, microcephaly, and …
Is HSP a form of MS?
HSP shares several clinical features of the progressive phase in Multiple Sclerosis (MS) which is a chronic neurodegenerative disease characterized by multiple areas of central nervous system (CNS) inflammation, demyelination and axonal loss.
Is Hereditary spastic paraplegia painful?
The pain is not directly due to HSP itself but is instead often caused by muscle weakness and gait abnormalities resulting from HSP. As certain muscles become weaker, other muscles need to compensate for that weakness. Compensatory measures create an awkward gait that causes strain on many muscles and joints.
How is spastic diplegia related to cerebral palsy?
Spastic diplegia is a type of cerebral palsy that primarily affects the legs. If not properly managed, it can significantly affect one’s growth and ability to walk. Fortunately, the impact of motor impairments caused by cerebral palsy can be managed by promoting neuroplasticity.
Is there such a thing as hereditary spastic paraplegia?
General Discussion. The hereditary spastic paraplegias (HSP) are a large group of inherited neurologic disorders that share the primary symptom of difficulty walking due to muscle weakness and muscle tightness (spasticity) in the legs.
Where can I search for spastic diplegia infantile type?
PubMed is a searchable database of medical literature and lists journal articles that discuss Spastic diplegia infantile type. Click on the link to view a sample search on this topic. Questions sent to GARD may be posted here if the information could be helpful to others.
What to do for spastic diplegia in legs?
Botox and muscle relaxants block signals that cause spastic muscles to tighten. This helps delay the progression of contractures and provides temporary spasticity relief. Because spastic diplegia primarily affects the muscles in the legs, oral medications that affect the entire body are generally not ideal.