How does cathepsin K work?

Cathepsin K is a protease, which is defined by its high specificity for kinins, that is involved in bone resorption. The enzyme’s ability to catabolize elastin, collagen, and gelatin allows it to break down bone and cartilage.

What does cathepsin B do?

Structurally, cathepsin B is a bilobal protein with cysteine, histidine, and aspartic acid forming active site of the enzyme at the interface between the two lobes [37]. Cathepsin B can function as an endopeptidase, cleaving internal peptide bonds, as well as an exopeptidase (carboxydipeptidase activity) [37, 38].

Where does cathepsin B cleave?

Several studies have proposed crucial extralysosomal functions for cathepsin B. In addition to being localized in the lysosome, cathepsin B (or alternatively spliced variants of cathepsin B) can be found on the surface or in the periplasmic space of tumor cells [6–11], where it can promote invasion.

When do we need osteoclasts?

This function is critical in the maintenance, repair, and remodelling of bones of the vertebral skeleton. The osteoclast disassembles and digests the composite of hydrated protein and mineral at a molecular level by secreting acid and a collagenase, a process known as bone resorption.

What stimulates RANKL?

Parathyroid hormone (PTH) stimulates osteoclast formation by binding to its receptor on stromal/osteoblastic cells and stimulating the production of receptor activator of NFkappaB ligand (RANKL) and inhibiting the expression of osteoprotegerin (OPG).

Are there any other cathepsin K inhibitors for osteoporosis?

Cathepsin K Inhibitors for Osteoporosis: Biology, Potential Clinical Utility, and Lessons Learned | Endocrine Reviews | Oxford Academic There is a clear need for additional therapeutic options for the treatment of osteoporosis. This review summarizes the underlying biology and potential clinical

What are the potential clinical uses of cathepsin K?

Potential Clinical Role of Cathepsin K Inhibitors Conclusion and Future Directions Abbreviations: Acknowledgments References < Previous Next > Article Navigation Cathepsin K Inhibitors for Osteoporosis: Biology, Potential Clinical Utility, and Lessons Learned Matthew T Drake, Matthew T Drake

Is there a need for additional therapeutic options for osteoporosis?

There is a clear need for additional therapeutic options for the treatment of osteoporosis. This review summarizes the underlying biology and potential clinical We use cookies to enhance your experience on our website.By continuing to use our website, you are agreeing to our use of cookies.

Who is the Mayo Clinic endocrinologist for osteoporosis?

Address all correspondence and requests for reprints to: Sundeep Khosla, MD, Division of Endocrinology and Kogod Center on Aging, Mayo Clinic College of Medicine, Rochester]